Coronary artery disease (CAD) is the most prevalent cardiovascular disease globally and a leading cause of mortality and morbidity. Although substantial clinical evidence supports the benefits of physical activity, healthy diet, and cessation of nicotine use in preventing CAD, only a minority of individuals engage in rehabilitation programs aimed at CAD prevention.

The Focus
The CARRIER consortium centers its efforts on primary and secondary prevention of CAD through a regional collaboration involving clinicians, health service researchers, legal experts, and data scientists. Their focus is on investigating big data-driven, participative self-care interventions for CAD prevention. Leveraging internet and smartphone-based self-care interventions can extend the reach of these interventions, while data-driven prediction modeling enables targeted and personalized approaches.

The Research
The CARRIER project integrates clinical big data from various sources (hospitals and general practitioners) with socioeconomic big data and artificial intelligence to develop models for CAD prevention interventions delivered through an electronic lifestyle coach (eCoach).

A prognostic model helps identify individuals at increased risk for CAD (primary prevention) and those with established CAD (secondary prevention) as the target population. Participants, in collaboration with clinicians, will co-create personalized health management plans supported by the eCoach to promote adherence. Data generated by the eCoach on participants' lifestyles will inform and validate predictive models estimating personalized benefits from lifestyle modifications. This feedback loop will inform clinicians and influence the eCoach's behavior to optimize CAD prevention strategies.

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Contact person:

prof. dr. ir. A.L.A.J. Dekker (Andre)

Principal investigators

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In the past decade, there has been significant progress in understanding sex- and gender-based differences in cardiovascular diseases (CVD). However, this knowledge remains scattered across medical literature, highlighting the need for a centralized platform accessible to healthcare professionals, scientists, policymakers, and patients. The IMPRESS consortium aims to establish a knowledge platform focused on gathering, summarizing, and prioritizing existing knowledge related to sex- and gender-specific aspects of CVD. This initiative seeks to promote the implementation of existing knowledge into clinical practice, identify knowledge gaps, and inform policymakers about areas requiring additional attention. In substantial portions of women with symptoms of myocardial ischemia, obstructive disease in the epicardial coronary arteries is absent. Currently, such women undergo multiple diagnostic tests, which do not always result in a conclusive diagnosis. IMPRESS seeks to reduce missed and delayed diagnoses of heart diseases in women, improving cardiovascular care outcomes nationwide. The knowledge platform will serve as a national resource, fostering collaboration and supporting the adoption of sex- and gender-sensitive practices in cardiovascular medicine. The Research IMPRESS consolidates existing knowledge, fosters research, and implements findings into practice wherever possible (for example by creating a Decision Support Tool for primary care and for cardiologists). Within the IMPRESS consortium, the following studies are being conducted: Delphi study: delayed or missed diagnosis of heart disease Silent heart attacks: causes, symptoms, and risk factors of silent myocardial infarctions UMCU-IMPRESS pilot study: undetected coronary microvascular disease (CMD) Peripheral-Flow: LASCA technique in CMD Dutch registry of coronary function tests
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